Welcome to Tepid Vax Summer- POLITICO

With help from Tyler Wayant

What have you done to me lately As the summer of our third pandemic approaches, it’s easy to get frustrated with vaccines.

It is not effective against variables and sub-variables that are still mocking us. They do not prevent the ongoing transmission of infection – and re-infection.

They have not regained the normality we were in before the pandemic (in part because so many people refused to receive the vaccine, often for ideological reasons).

We still need more reinforcements.

But vaccines are a victim of their own success. We complain about them because we have high expectations for them – because they have done so well.

As June 2022 approaches, it’s easy to forget what October 2020 was. At the time, we were hoping for a vaccine — one — that would be at least 50 percent effective. Instead, the world has many more vaccines – and more in the pipeline.

The ones used here in the US — Pfizer, Moderna, and to a lesser extent because of thrombosis risks, Johnson & Johnson — are more than 50 percent effective in protecting us from serious illness and death. Hundreds of people still die from Covid-19 every day. But not in the thousands.

Whatever their flaws, coronavirus vaccines are exceptional. William Hanage, an epidemiologist at Harvard University, reminded Knightley that they saved millions of lives. The pandemic has placed horrific pressures on health care systems and health care workers. But everything would have been worse without the shots.

“Remember back in 2020, you had only one way to get immunity – and that was to get infected. Sick. That was too risky for the elderly in particular,” Hanage said.

But that was then. Our expectations – and our pandemic fatigue – are now higher. The question about vaccines now is what’s next. The answer can come in one of several forms.

The government now confirms both vaccination and treatment. Ashish Jha, the White House coronavirus response coordinator, said public health officials “are making sure we have a new generation of vaccines that are being worked on now, that we have the treatments and tests available and we have the resources.”

The Food and Drug Administration and its advisory board are studying Whether and how vaccines should be modified to provide better protection against variants. The snapshots we’ve got now were in response to the original, “wild” or “ancestral” version of the virus that spread around the world in early 2020. We’ve been through two-thirds of the Greek alphabet since then. An administration official told Nightly that more data about the reworked version should come in a few weeks.

But even if vaccines are updated to better target the virus as it exists today – or to make the protective response more permanent – it will not guarantee that a new vaccine will effectively protect us against another mutation should one emerge. But broader protection should help.

The Holy Grail is a coronavirus vaccine, One that would protect us from all variants and subtypes. The science is within reach — but so far, the money isn’t, Eric Topol, MD, cardiologist, medical school professor and founder of the Scripps Research Translational Institute, told Nightly. Congressional Republicans have even ignored the slashed pandemic spending bill that President Joe Biden requested. Nor has any international consortium, from countries or other charities, come forward to fund what is essentially Operation Warp Speed ​​Part 2.

This lack of urgency – and funding – worries Topol. “The cracks[in protection]against serious and dangerous diseases have not been sufficiently recognized,” Topol said. “We have holes in the armor.”

Another path is the development of a nasal (or possibly an oral) vaccine. That would give us “mucosal immunity” – which means it would target our noses so the virus can’t get in. We will be less likely to get infected and less likely to spread the coronavirus to others. Few of them are in clinical trials already.

Antibodies produced by conventional injection are like “guards of the immune system,” flushing viruses out of our cells before they can harm us, said Emily Landon, an infectious disease specialist at the University of Chicago Medicine. The nasal vaccine will create a “repellent guard” – an outer perimeter of protection.

Plus, the nasal spray may have fewer side effects, Topol said. And there are no needles, which is a bonus because needle phobia is one reason some people have avoided vaccination even now.

“Heterogeneous” immunity – scientists’ multisyllable term for Mix and match vaccines Another possible tool. So a person who got an mRNA injection might get a booster dose of a more traditional type of vaccine. It’s being studied – but it’s challenging, in part because there are so many possible combinations of vaccines, doses, and time periods. (In addition, vaccine makers have no incentive to conduct expensive studies that hand over a portion of their market to a competitor.)

The last track – and it’s not the one most of us want to hear – is just that We (or at least the high risk among us) may actually need injections twice a year Landon said for some time to come.

We get flu shots (or we recommend that) every year — but the flu only spreads for a few months at a time. At the moment, the Covid virus is a year-round phenomenon, moving from one area or hotspot to another and back again, so a shot once a year is not enough. In addition, she said, “Our immunity to respiratory viruses does not last long. It never did.”

Welcome to Politico Knightley. Here is Tyler. I’ll have more to say below, but I wanted to thank all of our readers. Your time and trust in us means more than you know. Connect with news, tips and ideas on [email protected]. Or connect with tonight’s author on Twitter at Tweet embed.

Michael Sussman acquitted of charges brought by Special Counsel Durham: First courtroom test of Special Counsel John Durham The defeat ended today as a federal jury found the Democratic attorney not guilty of making a false statement to the FBI. About allegations of computer links between Donald Trump and Russia. The jury deliberated for about six hours before Susman, 57, was acquitted of one felony charge he faced: that he lied when he claimed he was acting on behalf of any agent in alerting the FBI to allegations that a secret server linked Trump and a Bank of Moscow with ties to the Russian president Vladimir Putin.

Supreme Court refuses to block Texas ‘censorship’ law on social media: Supreme court A Texas law that bans online platforms from restricting users’ posts based on their political views has been bannedWhich is a huge plus for social media companies. Tech industry groups said the law would violate companies’ First Amendment rights and force them to carry “the ugliest rhetoric imaginable — such as white supremacist statements, Nazi rhetoric, Russian propaganda, Holocaust denial, and terrorist organization recruitment.”

Rising temperatures could cause more power outages this summer. Texas, West and Midwest Brace for potentially dangerous and costly power outages this summer due to severe weather and fluctuating gas prices But regulators are divided on how to maintain power now and next summer. In the Midwest, premature coal plant retirements and a lack of alternative energy threaten to create an unstable gap between supply and demand as temperatures rise by June. Old coal and gas plants across the West also risk being forced to reduce production or shut down completely as intense heat and drought conditions threaten their access to water and disrupt needed maintenance.

His standards advisor, Boris Johnson, said: Standards Advisor Boris Johnson has He suggested that the British Prime Minister may have broken the ministerial law when the police fined him For disobeying the coronavirus lockdown rules. Christopher Giddet – Johnson’s independent adviser on ministers’ interests – wrote today that there is a “legitimate question” about whether Johnson has broken the law governing ministers’ behaviour, referring to the Partygate scandal involving multiple lockout parties in Downing Street.

From the EU to Africa: Beware Russia’s food message – European leaders Today I appealed to African countries not to fall into a propaganda campaign led by the Kremlin It depicts an imminent global food crisis as a result of Western sanctions against Russia, giorgio nights And the Jacopo Barigazzi Type.

Africa and the Middle East risk being hit hard by Ukraine’s inability to ship its massive grain crops from the Black Sea, but Russian President Vladimir Putin has repeatedly accused the West of being responsible for disrupting global supplies of grain and fertilizer.

He repeated his message last Saturday, when he told French President Emmanuel Macron and German Chancellor Olaf Schulz that the rupture in the food webs should be blamed on Western countries, not his invasion of Ukraine.

At the European Council summit in Brussels today, EU leaders rejected this claim and insisted that Moscow was to blame for the blockage of grain in the port of Odessa.

related – night Tyler Wayant Email messages:

“We are in a rut.” I doubt it was written in Nightly before, but it’s a phrase we say to each other all the time, at least once every two months to cover the pandemic, the tune that started it all in Nightly. Every once in a while, we look across the landscape of pandemic issues, finding it hard to tell what hasn’t been said yet, and what hasn’t been said before.

Well, I’m on my last nightly trip. After today, I am starting a new role at POLITICO, working with our exceptional Congressional team.

And after hundreds of editions, doing basically every job you can get on this newsletter, I’m at a loss as to what to say.

I have written nine different versions of this item in the past week and a half. A few of them sounded like grim graduation speeches, as she said “I’m tired of being sad and sad because I’m tired” several times. In five of the previous editions, I used the phrase “I’m not a guy who literally writes a farewell column before going to therapy.” Cringe is not a strong enough word.

I tried to get out of the predicament by doing things in my personal life. I went for a walk. I watched Maryland win the National Lacrosse Championship. I rode a mechanical bull. I bought copious amounts of fudge on vacation.

But in the end, I got off the hook the way we often get out while reporting on the pandemic and other matters: I got bogged down in it. I wrote erotica.

What she wrote on the day of the Ovaldi shootings, “Mass shootings have become America’s tragedy.” This is another rut. We are stuck in a cycle of something terrible and someone needs to say it clearly.

It seems that we need all the time in our present policy to explain this erotica clearly. Most of the country’s political issues seem to be mosquitoes stuck in amber, and despite the efforts of eccentric billionaires to extract their DNA and possibly create monsters, they are still quite stuck.

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